I think that dissos are especially able to do other things to you as they do 2 things that psychedelics can't.
1. They mostly came from anesthetic research and have these effects that knock your body out (and sometimes even stimulating effects at the same time like PCP and it's analogues). That means they force your body into a state that is forced to focus on the inner experience, shaping your free will in ways that is weird to say the least. And some parts of perception get turned off too, like the integration of sensory information, resulting in funny associations, and less funny ones. NMDA Receptors are turned off, so that also created this "disconnected awareness".
So this results in that:
Turning Off Signal Relay: By lodging inside the receptor channel, they prevent glutamate from opening the gate for calcium and sodium ions. This effectively cuts the electrical signal between the thalamus (the brain's sensory relay station) and the cerebral cortex (the area responsible for conscious perception).
Disrupted Pathways: This blockade specifically targets pathways responsible for pain perception, proprioception or sense of body position, and multisensory integration. The body may still receive sensory input (eyes see, skin feels), but the brain physically cannot assemble these signals into a coherent picture of reality.
2. The anesthetic part of them takes away a fear that pushes you to physical or mental decisions that you would shape your regular non disso trip significantly - so you get a synthetic fearlessness or letting go that is the foundation of deeper trips that you normally self sabotage in regular psychedelics trips. This way ego dissolution and very deep states occur in different intensity.
Sadly dissos are also way more toxic and dangerous or life altering in all kinds of ways. The level of confusion is just rivaled by deliriants like datura or scopolamine, where "real hallucinations" are the common thing, where you talk with people that arent there and look real.
As many know Datura is frequently used especially in latin america to turn people into zombies (not literal like iboga burials) without will -
they just tell ppl that had a fenta like tiny amount on their skin to help empty out their flat including bed and furniture etc into a van and go with them to the bank to pickup all their funds - later they can not argue legally as the cctv shows them picking it up willingly etc.
Also datura has caused death more than once, so that is a big nono, also why would you want the extremest possible dry mouth possible for 72h after which you wake up in a hospital with them telling you you had a stroke, gifted away all you belongings and have to go to a mental asylum or jail because you caused x trouble on top, go for it. XD
Where with dissos you have the anesthetic part where you are not able to feel pain, process what is going on inside or outside of you, while being stimulated and running around with PCP as example, resulting in ppl cutting off parts of their body or behaving zombies with superhuman strength, explaining how their mom is a 1000 year old machine that has the purpose to print agents of healing that need to collect souls from evil people and animals or sth like that. There is a famous story of this rapper who cut of his penis on it.
Also the substances itself are way more toxic, you know the whole ketamine bladder thing, compared to natural psychedelics that usually just show some signs of mild poisoning for a short time.
Here is a short paragraph from AI that outlines what is blocked with dissos and causes what:
Also equally crazy and some say even more insane than DMT is Salvia Divinorum, most know that stuff. Usually less dangerous (to your body) but none the less equally confusing.
But psychedelics should never be for hedonism only, but these can be on the hard end of things, I mean you can have equally life changing and sometimes also funny experiences of heroic doses or normal doses of Tryptamines that give you the same depth of experience.
If you want to scar your soul a little with less physical danger you could try DPT or so, the dark weird cold cousin of DMT.
Imagine the intensity of DMT with a dark twist, yeah, made me hesitate too.
I also felt drawn to interesting dissos in smaller doses more than once, but usually, after consuming my fair share of trip reports, descided against them. Even the "friendlier ones" like 3-Meo-PCE can and will have effects that can last up to weeks where you, well will get to know yourself, but can have serious long lasting after effects - like losing your job - or are flat out dangerous without some unemployed friend or ultra cool retired dad that is there for you 24/7.
For me it's mostly just the occasional tageted higher dose of shrooms or something equally "classic and physically safe"-
or the professionally assisted week long retreat challenge - than the experimentation with the basics of my reality.
That being said - I would go for some professional Ketamine therapy if I could in my area.
But dissos often times have a big problem with forming addiction while having a really steep tolerance curve (while being destructive to your bladder etc), and developing true delusion and "redosing problems aka accelerated addiction" - is way tooeasy on these.
I have nothing against deep experimentation - in the contrary, I am well informed on quiet some exotic stuff and am kind of on the wavelenght of "do what thou wilt" - but I just wanted to highlight the disclaimer in neon colored letters here.
I am usually no substance doomer, but this segment of substances is no joke & if I saved one person from life long institutional exploitation and so on, you're welcome
In that sense - don't panic it's organic -yeeea maybe not datura, but you get what I mean.